Assay Detail
Binding
CHEMBL3591656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of his-tagged PRMT6 (unknown origin) expressed in human A375 cells assessed as reduction in H3R2 methylation at 0.01 to 20 uM incubated for 48 hrs by Western blot method
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 6 (CHEMBL1275221) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.20 | 6.20 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589039 | — | — | 2 | 6.20 |
| CHEMBL3589038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589039 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL3589038 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589039 | — | Inhibition | - | % | - |