Assay Detail
Binding
CHEMBL3591915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.93 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589372 | — | — | 1 | 5.87 |
| CHEMBL3589370 | — | — | 1 | 5.34 |
| CHEMBL3589371 | — | — | 1 | 5.24 |
| CHEMBL3589324 | — | — | 1 | 5.12 |
| CHEMBL3589377 | — | — | 1 | 4.90 |
| CHEMBL3589379 | — | — | 1 | 4.81 |
| CHEMBL3589376 | — | — | 1 | 4.73 |
| CHEMBL3589375 | — | — | 1 | 4.63 |
| CHEMBL3589378 | — | — | 1 | 4.57 |
| CHEMBL3589320 | — | — | 1 | 4.04 |
| CHEMBL3589321 | — | — | 1 | - |
| CHEMBL3589322 | — | — | 1 | - |
| CHEMBL3589323 | — | — | 1 | - |
| CHEMBL3589373 | — | — | 1 | - |
| CHEMBL3589374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589372 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3589370 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL3589371 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL3589324 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3589377 | — | IC50 | = | 12570.0 | nM | 4.90 |
| CHEMBL3589379 | — | IC50 | = | 15560.0 | nM | 4.81 |
| CHEMBL3589376 | — | IC50 | = | 18480.0 | nM | 4.73 |
| CHEMBL3589375 | — | IC50 | = | 23640.0 | nM | 4.63 |
| CHEMBL3589378 | — | IC50 | = | 26870.0 | nM | 4.57 |
| CHEMBL3589320 | — | IC50 | = | 91560.0 | nM | 4.04 |
| CHEMBL3589321 | — | IC50 | = | 125800.0 | nM | - |
| CHEMBL3589322 | — | IC50 | = | 465500.0 | nM | - |
| CHEMBL3589323 | — | IC50 | = | 345900.0 | nM | - |
| CHEMBL3589373 | — | IC50 | = | 781500.0 | nM | - |
| CHEMBL3589374 | — | IC50 | = | 967700.0 | nM | - |