Assay Detail
Binding
CHEMBL3592015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.38 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589372 | — | — | 1 | 6.50 |
| CHEMBL3589370 | — | — | 1 | 6.06 |
| CHEMBL3589324 | — | — | 1 | 5.99 |
| CHEMBL3589371 | — | — | 1 | 5.78 |
| CHEMBL3589377 | — | — | 1 | 5.74 |
| CHEMBL3589379 | — | — | 1 | 5.58 |
| CHEMBL3589376 | — | — | 1 | 5.56 |
| CHEMBL3589375 | — | — | 1 | 5.45 |
| CHEMBL3589378 | — | — | 1 | 5.40 |
| CHEMBL3589320 | — | — | 1 | 4.84 |
| CHEMBL3589321 | — | — | 1 | 4.70 |
| CHEMBL3589323 | — | — | 1 | 4.25 |
| CHEMBL3589322 | — | — | 1 | 4.15 |
| CHEMBL3589373 | — | — | 1 | - |
| CHEMBL3589374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589372 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3589370 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3589324 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3589371 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3589377 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3589379 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL3589376 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL3589375 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL3589378 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL3589320 | — | IC50 | = | 14570.0 | nM | 4.84 |
| CHEMBL3589321 | — | IC50 | = | 20120.0 | nM | 4.70 |
| CHEMBL3589323 | — | IC50 | = | 56890.0 | nM | 4.25 |
| CHEMBL3589322 | — | IC50 | = | 71350.0 | nM | 4.15 |
| CHEMBL3589373 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL3589374 | — | IC50 | = | 154780.0 | nM | - |