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Assay Detail

CHEMBL3592121

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Functional
Antiproliferative activity against human SW620 cells after 72 hrs by sulforhodamine B assay
15
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW-620
Confidence 1 — Organism
Curated By Autocuration

Target

SW-620 (CHEMBL612262)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
Chen L, Liang Y, Song T, Anjum K, Wang W, Yu S, Huang H, Lian XY, Zhang Z.
Bioorg Med Chem Lett (2015) 25 : 2629 -2633
PubMed 25981689 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.32 6.44
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3588939 2 6.44
CHEMBL2152488 1 6.39
CHEMBL3588937 2 6.00
CHEMBL53463 DOXORUBICIN 4.0 1 5.88
CHEMBL233930 ASTRAGALIN 1 5.34
CHEMBL3588938 1 5.28
CHEMBL1644111 TRANS-PHYTOL 1 5.23
CHEMBL3588942 1 5.12
CHEMBL3588945 1 5.11
CHEMBL3588941 1 4.99
CHEMBL3588943 1 4.66
CHEMBL3588944 1 4.45
CHEMBL3588940 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3588939 IC50 = 360.0 nM 6.44
CHEMBL2152488 IC50 = 410.0 nM 6.39
CHEMBL3588937 IC50 = 990.0 nM 6.00
CHEMBL53463 DOXORUBICIN IC50 = 1330.0 nM 5.88
CHEMBL233930 ASTRAGALIN IC50 = 4600.0 nM 5.34
CHEMBL3588938 IC50 = 5250.0 nM 5.28
CHEMBL1644111 TRANS-PHYTOL IC50 = 5850.0 nM 5.23
CHEMBL3588942 IC50 = 7590.0 nM 5.12
CHEMBL3588945 IC50 = 7850.0 nM 5.11
CHEMBL3588941 IC50 = 10230.0 nM 4.99
CHEMBL3588943 IC50 = 21900.0 nM 4.66
CHEMBL3588944 IC50 = 35500.0 nM 4.45
CHEMBL3588940 IC50 = 47400.0 nM 4.32
CHEMBL3588937 Inhibition - % -
CHEMBL3588939 Inhibition - % -