Assay Detail
Functional
CHEMBL3592209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human HeLa cells over-expressing PI3K p110alpha incubated for 72 hrs by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.09 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589372 | — | — | 1 | 6.68 |
| CHEMBL3589370 | — | — | 1 | 6.62 |
| CHEMBL3589371 | — | — | 1 | 6.44 |
| CHEMBL3589324 | — | — | 1 | 6.33 |
| CHEMBL3589377 | — | — | 1 | 6.24 |
| CHEMBL3589379 | — | — | 1 | 6.23 |
| CHEMBL3589376 | — | — | 1 | 6.22 |
| CHEMBL3589378 | — | — | 1 | 6.11 |
| CHEMBL3589375 | — | — | 1 | 6.06 |
| CHEMBL3589320 | — | — | 1 | 5.81 |
| CHEMBL3589321 | — | — | 1 | 5.72 |
| CHEMBL3589322 | — | — | 1 | 5.71 |
| CHEMBL3589323 | — | — | 1 | 5.71 |
| CHEMBL3589373 | — | — | 1 | 5.70 |
| CHEMBL3589374 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589372 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3589370 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3589371 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3589324 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3589377 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3589379 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3589376 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3589378 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3589375 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3589320 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3589321 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3589322 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3589323 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL3589373 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL3589374 | — | IC50 | = | 1990.0 | nM | 5.70 |