Assay Detail
Functional
CHEMBL3592210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against human SKOV3 cells expressing PIK3CA mutant incubated for 72 hrs by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.92 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589372 | — | — | 1 | 5.87 |
| CHEMBL3589370 | — | — | 1 | 5.78 |
| CHEMBL3589371 | — | — | 1 | 5.45 |
| CHEMBL3589324 | — | — | 1 | 5.33 |
| CHEMBL3589377 | — | — | 1 | 5.24 |
| CHEMBL3589379 | — | — | 1 | 5.18 |
| CHEMBL3589376 | — | — | 1 | 5.12 |
| CHEMBL3589378 | — | — | 1 | 4.91 |
| CHEMBL3589375 | — | — | 1 | 4.84 |
| CHEMBL3589320 | — | — | 1 | 4.69 |
| CHEMBL3589321 | — | — | 1 | 4.66 |
| CHEMBL3589323 | — | — | 1 | 4.23 |
| CHEMBL3589322 | — | — | 1 | 4.22 |
| CHEMBL3589373 | — | — | 1 | 4.13 |
| CHEMBL3589374 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589372 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3589370 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3589371 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3589324 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL3589377 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL3589379 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL3589376 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL3589378 | — | IC50 | = | 12340.0 | nM | 4.91 |
| CHEMBL3589375 | — | IC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL3589320 | — | IC50 | = | 20540.0 | nM | 4.69 |
| CHEMBL3589321 | — | IC50 | = | 21670.0 | nM | 4.66 |
| CHEMBL3589323 | — | IC50 | = | 58530.0 | nM | 4.23 |
| CHEMBL3589322 | — | IC50 | = | 60460.0 | nM | 4.22 |
| CHEMBL3589373 | — | IC50 | = | 74530.0 | nM | 4.13 |
| CHEMBL3589374 | — | IC50 | = | 78450.0 | nM | 4.11 |