Assay Detail
Binding
CHEMBL3592702
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Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 45 mins by AlphaScreen competitive inhibition assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.09 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589156 | — | — | 1 | 6.00 |
| CHEMBL3589012 | — | — | 1 | 5.92 |
| CHEMBL3260853 | — | — | 1 | 5.89 |
| CHEMBL3589019 | — | — | 1 | 5.57 |
| CHEMBL3589024 | — | — | 1 | 5.48 |
| CHEMBL2323032 | — | — | 1 | 5.42 |
| CHEMBL578512 | — | — | 1 | 5.42 |
| CHEMBL3589022 | — | — | 1 | 5.39 |
| CHEMBL2323033 | — | — | 1 | 5.23 |
| CHEMBL3589011 | — | — | 1 | 4.92 |
| CHEMBL2323029 | — | — | 1 | 4.89 |
| CHEMBL3589160 | — | — | 1 | 4.75 |
| CHEMBL2323028 | — | — | 1 | 4.68 |
| CHEMBL3589158 | — | — | 1 | 4.41 |
| CHEMBL3589025 | — | — | 1 | 4.28 |
| CHEMBL3589021 | — | — | 1 | 4.20 |
| CHEMBL3589161 | — | — | 1 | 4.13 |
| CHEMBL3589157 | — | — | 1 | - |
| CHEMBL3589023 | — | — | 1 | - |
| CHEMBL3589159 | — | — | 1 | - |
| CHEMBL3589020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589156 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3589012 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3260853 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3589019 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL3589024 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL2323032 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL578512 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL3589022 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2323033 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL3589011 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL2323029 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL3589160 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL2323028 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL3589158 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL3589025 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL3589021 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL3589161 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL3589157 | — | Ki | > | 130000.0 | nM | - |
| CHEMBL3589023 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3589159 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL3589020 | — | Ki | = | 120000.0 | nM | - |