Assay Detail
Functional
CHEMBL3592709
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.37 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589012 | — | — | 1 | 5.96 |
| CHEMBL2323033 | — | — | 1 | 5.75 |
| CHEMBL2323029 | — | — | 1 | 4.39 |
| CHEMBL1956161 | — | — | 1 | - |
| CHEMBL2323028 | — | — | 1 | - |
| CHEMBL3589011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589012 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2323033 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2323029 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1956161 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL2323028 | — | IC50 | = | 430000.0 | nM | - |
| CHEMBL3589011 | — | IC50 | = | 300000.0 | nM | - |