Assay Detail
Functional
CHEMBL3592750
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.89 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3590001 | — | — | 1 | 8.77 |
| CHEMBL3590000 | — | — | 1 | 8.08 |
| CHEMBL3589999 | — | — | 1 | 7.60 |
| CHEMBL3589993 | — | — | 1 | 6.89 |
| CHEMBL3590004 | — | — | 1 | 6.43 |
| CHEMBL3589994 | — | — | 1 | 6.29 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.25 |
| CHEMBL3589995 | — | — | 1 | 6.17 |
| CHEMBL3589998 | — | — | 1 | 5.02 |
| CHEMBL3589988 | — | — | 1 | 4.96 |
| CHEMBL3589997 | — | — | 1 | 4.96 |
| CHEMBL3589992 | — | — | 1 | 4.92 |
| CHEMBL3589996 | — | — | 1 | 4.92 |
| CHEMBL3590003 | — | — | 1 | 4.85 |
| CHEMBL3590002 | — | — | 1 | 4.77 |
| CHEMBL3589989 | — | — | 1 | 4.68 |
| CHEMBL3589987 | — | — | 1 | 4.58 |
| CHEMBL3589990 | — | — | 1 | - |
| CHEMBL3589991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3590001 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3590000 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3589999 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3589993 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3590004 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3589994 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3589995 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3589998 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3589988 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3589997 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3589992 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3589996 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3590003 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3590002 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3589989 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3589987 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3589990 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589991 | — | IC50 | > | 20000.0 | nM | - |