Assay Detail
Functional
CHEMBL3592751
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Antiproliferative activity against human M21 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.15 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.80 |
| CHEMBL3590001 | — | — | 1 | 8.62 |
| CHEMBL3590000 | — | — | 1 | 8.00 |
| CHEMBL3589999 | — | — | 1 | 7.57 |
| CHEMBL3589993 | — | — | 1 | 6.77 |
| CHEMBL3590004 | — | — | 1 | 6.26 |
| CHEMBL3589994 | — | — | 1 | 6.15 |
| CHEMBL3589995 | — | — | 1 | 6.02 |
| CHEMBL3589988 | — | — | 1 | 4.80 |
| CHEMBL3590003 | — | — | 1 | 4.77 |
| CHEMBL3590002 | — | — | 1 | 4.72 |
| CHEMBL3589989 | — | — | 1 | 4.68 |
| CHEMBL3589992 | — | — | 1 | 4.54 |
| CHEMBL3589987 | — | — | 1 | 4.46 |
| CHEMBL3589991 | — | — | 1 | - |
| CHEMBL3589990 | — | — | 1 | - |
| CHEMBL3589996 | — | — | 1 | - |
| CHEMBL3589997 | — | — | 1 | - |
| CHEMBL3589998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3590001 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3590000 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3589999 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3589993 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3590004 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3589994 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3589995 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3589988 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3590003 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3590002 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3589989 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3589992 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3589987 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3589991 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589990 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589996 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589997 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589998 | — | IC50 | > | 20000.0 | nM | - |