Assay Detail
Binding
CHEMBL3594608
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Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 4.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.22 |
| CHEMBL3593612 | — | — | 1 | 5.40 |
| CHEMBL1412304 | — | — | 1 | 5.35 |
| CHEMBL3593604 | — | — | 1 | 5.26 |
| CHEMBL347000 | — | — | 1 | 5.26 |
| CHEMBL3593605 | — | — | 1 | 4.68 |
| CHEMBL3593613 | — | — | 1 | 4.47 |
| CHEMBL1604946 | — | — | 1 | 4.42 |
| CHEMBL3593610 | — | — | 1 | 4.41 |
| CHEMBL1528711 | — | — | 1 | 4.39 |
| CHEMBL3593611 | — | — | 1 | 4.36 |
| CHEMBL129261 | — | — | 1 | 4.30 |
| CHEMBL3593800 | — | — | 1 | 4.30 |
| CHEMBL341154 | — | — | 1 | - |
| CHEMBL1570910 | — | — | 1 | - |
| CHEMBL3593801 | — | — | 1 | - |
| CHEMBL1532040 | — | — | 1 | - |
| CHEMBL3593799 | — | — | 1 | - |
| CHEMBL1605831 | — | — | 1 | - |
| CHEMBL1532279 | — | — | 1 | - |
| CHEMBL3593609 | — | — | 1 | - |
| CHEMBL3593608 | — | — | 1 | - |
| CHEMBL3593607 | — | — | 1 | - |
| CHEMBL3593606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3593612 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1412304 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3593604 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL347000 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3593605 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL3593613 | — | Ki | = | 33500.0 | nM | 4.47 |
| CHEMBL1604946 | — | Ki | = | 38500.0 | nM | 4.42 |
| CHEMBL3593610 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL1528711 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL3593611 | — | Ki | = | 43500.0 | nM | 4.36 |
| CHEMBL129261 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL3593800 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL341154 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1570910 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593801 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1532040 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593799 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1605831 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1532279 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593609 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593608 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593607 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3593606 | — | Ki | > | 50000.0 | nM | - |