Assay Detail
Binding
CHEMBL3594613
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Inhibition of DHODH (unknown origin) using L-DHO, DUQ, DCIP as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by multilabel plate reader analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.11 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 7.92 |
| CHEMBL3593806 | — | — | 1 | 7.89 |
| CHEMBL3593805 | — | — | 1 | 7.55 |
| CHEMBL3593251 | — | — | 1 | 6.68 |
| CHEMBL3593804 | — | — | 1 | 6.52 |
| CHEMBL3593802 | — | — | 1 | 5.86 |
| CHEMBL3593808 | — | — | 1 | 5.11 |
| CHEMBL578185 | — | — | 1 | 5.01 |
| CHEMBL571285 | — | — | 1 | 4.72 |
| CHEMBL3593812 | — | — | 1 | 4.70 |
| CHEMBL3593987 | — | — | 1 | 4.70 |
| CHEMBL3593996 | — | — | 1 | 4.64 |
| CHEMBL576423 | — | — | 1 | 4.55 |
| CHEMBL3593813 | — | — | 1 | 4.55 |
| CHEMBL3593992 | — | — | 1 | 4.51 |
| CHEMBL3593803 | — | — | 1 | 4.50 |
| CHEMBL3593983 | — | — | 1 | 4.43 |
| CHEMBL3593995 | — | — | 1 | 4.42 |
| CHEMBL3593989 | — | — | 1 | 4.40 |
| CHEMBL3593985 | — | — | 1 | 4.38 |
| CHEMBL3593807 | — | — | 1 | 4.33 |
| CHEMBL3593993 | — | — | 1 | 4.32 |
| CHEMBL3593981 | — | — | 1 | 4.30 |
| CHEMBL3593984 | — | — | 1 | 4.29 |
| CHEMBL3593990 | — | — | 1 | 4.26 |
| CHEMBL3593986 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3593806 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3593805 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3593251 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3593804 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3593802 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3593808 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL578185 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL571285 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3593812 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3593987 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3593996 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL576423 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3593813 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3593992 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3593803 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3593983 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3593995 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3593989 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3593985 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3593807 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3593993 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3593981 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3593984 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3593990 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3593986 | — | IC50 | = | 56000.0 | nM | 4.25 |