Assay Detail
Binding
CHEMBL3594883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 6.57 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593922 | — | — | 1 | 7.57 |
| CHEMBL3593904 | — | — | 1 | 7.46 |
| CHEMBL3593918 | — | — | 1 | 7.42 |
| CHEMBL3593905 | — | — | 1 | 7.32 |
| CHEMBL3593903 | — | — | 1 | 7.27 |
| CHEMBL3593926 | — | — | 1 | 7.14 |
| CHEMBL3593932 | — | — | 1 | 7.10 |
| CHEMBL3593911 | — | — | 1 | 7.05 |
| CHEMBL3593924 | — | — | 1 | 6.92 |
| CHEMBL3593916 | — | — | 1 | 6.88 |
| CHEMBL3593930 | — | — | 1 | 6.82 |
| CHEMBL3593902 | — | — | 1 | 6.77 |
| CHEMBL3593912 | — | — | 1 | 6.73 |
| CHEMBL3593893 | — | — | 1 | 6.72 |
| CHEMBL3593915 | — | — | 1 | 6.69 |
| CHEMBL3593923 | — | — | 1 | 6.68 |
| CHEMBL3593894 | — | — | 1 | 6.67 |
| CHEMBL3593908 | — | — | 1 | 6.64 |
| CHEMBL3593928 | — | — | 1 | 6.64 |
| CHEMBL3593910 | — | — | 1 | 6.62 |
| CHEMBL3593914 | — | — | 1 | 6.59 |
| CHEMBL328710 | — | — | 1 | 6.58 |
| CHEMBL3593913 | — | — | 1 | 6.58 |
| CHEMBL3593927 | — | — | 1 | 6.50 |
| CHEMBL3593929 | — | — | 1 | 6.45 |
| CHEMBL3593897 | — | — | 1 | 6.44 |
| CHEMBL201986 | — | — | 1 | 6.44 |
| CHEMBL3593909 | — | — | 1 | 6.43 |
| CHEMBL3593896 | — | — | 1 | 6.37 |
| CHEMBL3593933 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593922 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL3593904 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL3593918 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL3593905 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL3593903 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL3593926 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL3593932 | — | Ki | = | 80.1 | nM | 7.10 |
| CHEMBL3593911 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3593924 | — | Ki | = | 121.5 | nM | 6.92 |
| CHEMBL3593916 | — | Ki | = | 131.1 | nM | 6.88 |
| CHEMBL3593930 | — | Ki | = | 151.7 | nM | 6.82 |
| CHEMBL3593902 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL3593912 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL3593893 | — | Ki | = | 191.3 | nM | 6.72 |
| CHEMBL3593915 | — | Ki | = | 204.3 | nM | 6.69 |
| CHEMBL3593923 | — | Ki | = | 208.7 | nM | 6.68 |
| CHEMBL3593894 | — | Ki | = | 212.4 | nM | 6.67 |
| CHEMBL3593908 | — | Ki | = | 229.1 | nM | 6.64 |
| CHEMBL3593928 | — | Ki | = | 228.6 | nM | 6.64 |
| CHEMBL3593910 | — | Ki | = | 239.7 | nM | 6.62 |
| CHEMBL3593914 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL3593913 | — | Ki | = | 263.2 | nM | 6.58 |
| CHEMBL328710 | — | Ki | = | 261.5 | nM | 6.58 |
| CHEMBL3593927 | — | Ki | = | 318.1 | nM | 6.50 |
| CHEMBL3593929 | — | Ki | = | 354.6 | nM | 6.45 |
| CHEMBL3593897 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL201986 | — | Ki | = | 362.5 | nM | 6.44 |
| CHEMBL3593909 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL3593896 | — | Ki | = | 431.7 | nM | 6.37 |
| CHEMBL3593933 | — | Ki | = | 455.7 | nM | 6.34 |
| CHEMBL3593917 | — | Ki | = | 465.1 | nM | 6.33 |
| CHEMBL3593919 | — | Ki | = | 528.5 | nM | 6.28 |
| CHEMBL3593901 | — | Ki | = | 522.1 | nM | 6.28 |
| CHEMBL3593925 | — | Ki | = | 590.5 | nM | 6.23 |
| CHEMBL86921 | — | Ki | = | 617.6 | nM | 6.21 |
| CHEMBL3593931 | — | Ki | = | 630.3 | nM | 6.20 |
| CHEMBL3593906 | — | Ki | = | 682.4 | nM | 6.17 |
| CHEMBL3593907 | — | Ki | = | 717.6 | nM | 6.14 |
| CHEMBL3593895 | — | Ki | = | 797.8 | nM | 6.10 |
| CHEMBL3593252 | — | Ki | = | 789.8 | nM | 6.10 |
| CHEMBL3593899 | — | Ki | = | 858.8 | nM | 6.07 |
| CHEMBL3593900 | — | Ki | = | 853.5 | nM | 6.07 |
| CHEMBL3593898 | — | Ki | = | 1116.2 | nM | 5.95 |
| CHEMBL3593921 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL3593920 | — | Ki | = | 1756.7 | nM | 5.75 |