Assay Detail
Binding
CHEMBL3595283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP3 (CHEMBL5083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.43 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593715 | — | — | 1 | 4.89 |
| CHEMBL3594137 | — | — | 1 | 4.47 |
| CHEMBL3594136 | — | — | 1 | 4.30 |
| CHEMBL3593716 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593715 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3594137 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3594136 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3593716 | — | IC50 | = | 91000.0 | nM | 4.04 |