Assay Detail
Binding
CHEMBL3595596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 recombinant wild type reverse transcriptase p66/p51 assessed as reduction in biotin deoxyuridine triphosphate (biotin-dUTP) incorporation using poly(rA)/oligo (dT)16 template and primer by spectrofluorometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.31 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.66 |
| CHEMBL3593877 | — | — | 1 | 6.33 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.09 |
| CHEMBL3593248 | — | — | 1 | 5.93 |
| CHEMBL3593512 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3593877 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL3593248 | — | IC50 | = | 1169.0 | nM | 5.93 |
| CHEMBL3593512 | — | IC50 | = | 2775.0 | nM | 5.56 |