Assay Detail
ADMET
CHEMBL3595916
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Cytotoxicity against human PBMC assessed as cell viability after 3 days by AlamarBlue assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.87 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593726 | — | — | 1 | 5.62 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 4.86 |
| CHEMBL3593723 | — | — | 1 | 4.52 |
| CHEMBL3593724 | — | — | 1 | 4.49 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | - |
| CHEMBL3593731 | — | — | 1 | - |
| CHEMBL3593730 | — | — | 1 | - |
| CHEMBL3593729 | — | — | 1 | - |
| CHEMBL3593728 | — | — | 1 | - |
| CHEMBL3593727 | — | — | 1 | - |
| CHEMBL3593725 | — | — | 1 | - |
| CHEMBL3593722 | — | — | 1 | - |
| CHEMBL3593555 | — | — | 1 | - |
| CHEMBL3593554 | — | — | 1 | - |
| CHEMBL3593553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593726 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL3593723 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3593724 | — | IC50 | = | 32510.0 | nM | 4.49 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 116600.0 | nM | - |
| CHEMBL3593731 | — | IC50 | - | — | - | |
| CHEMBL3593730 | — | IC50 | - | — | - | |
| CHEMBL3593729 | — | IC50 | - | — | - | |
| CHEMBL3593728 | — | IC50 | - | — | - | |
| CHEMBL3593727 | — | IC50 | - | — | - | |
| CHEMBL3593725 | — | IC50 | = | 701800.0 | nM | - |
| CHEMBL3593722 | — | IC50 | - | — | - | |
| CHEMBL3593555 | — | IC50 | = | 264700.0 | nM | - |
| CHEMBL3593554 | — | IC50 | - | — | - | |
| CHEMBL3593553 | — | IC50 | - | — | - |