Assay Detail
Binding
CHEMBL3596006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full-length HDAC6 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measured every 5 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.94 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593247 | — | — | 1 | 7.55 |
| CHEMBL3593411 | — | — | 1 | 7.45 |
| CHEMBL3593409 | — | — | 1 | 7.31 |
| CHEMBL3593407 | — | — | 1 | 6.99 |
| CHEMBL1173445 | LARGAZOLE | — | 1 | 6.78 |
| CHEMBL3593415 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593247 | — | IC50 | = | 28.11 | nM | 7.55 |
| CHEMBL3593411 | — | IC50 | = | 35.16 | nM | 7.45 |
| CHEMBL3593409 | — | IC50 | = | 48.55 | nM | 7.31 |
| CHEMBL3593407 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 165.6 | nM | 6.78 |
| CHEMBL3593415 | — | IC50 | = | 2849.0 | nM | 5.54 |