Assay Detail
Functional
CHEMBL3596042
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Immunosuppressive activity in Drosophila S2 cells expressing att-luc reporter gene assessed as inhibition of peptidoglycan-induced attacin production pre-treated for 1.5 hrs before peptidoglycan stimulation for 8 hrs by luciferase reporter gene assay
15
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Drosophila |
| Cell Type | S2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel DIF-1 derivatives that selectively suppress innate immune responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.98 | 5.43 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594292 | — | — | 1 | 5.43 |
| CHEMBL3594282 | — | — | 1 | 5.43 |
| CHEMBL3594286 | — | — | 1 | 5.42 |
| CHEMBL1437894 | — | — | 1 | 5.34 |
| CHEMBL2409648 | — | — | 2 | 5.34 |
| CHEMBL3594293 | — | — | 1 | 5.19 |
| CHEMBL3594284 | — | — | 1 | 5.00 |
| CHEMBL3594290 | — | — | 1 | 4.82 |
| CHEMBL3594289 | — | — | 1 | 4.78 |
| CHEMBL3594283 | — | — | 1 | 4.72 |
| CHEMBL3594287 | — | — | 1 | 4.68 |
| CHEMBL3594291 | — | — | 1 | 4.67 |
| CHEMBL3594288 | — | — | 1 | 4.63 |
| CHEMBL3594285 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594292 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3594282 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3594286 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1437894 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2409648 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3594293 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3594284 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3594290 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3594289 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3594283 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3594287 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL3594291 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3594288 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL3594285 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL2409648 | — | Inhibition | - | % | - |