Assay Detail
Binding
CHEMBL3598341
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Binding affinity to recombinant HIV-1 integrase catalytic core domain expressed in Escherichia coli assessed as inhibition of interaction with LEDFG/P75 by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.87 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180481 | — | — | 1 | 7.75 |
| CHEMBL3259895 | — | — | 1 | 7.22 |
| CHEMBL1230654 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180481 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3259895 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1230654 | — | IC50 | = | 2350.0 | nM | 5.63 |