Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3598351

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DPDPE from human DOR expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.
Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H.
Bioorg Med Chem Lett (2015) 25 : 2927 -2930
PubMed 26048798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 8.31 9.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL610012 1 9.39
CHEMBL567175 NALTRINDOLE 1 9.34
CHEMBL3596364 1 8.96
CHEMBL3596365 1 8.71
CHEMBL3596363 1 8.57
CHEMBL3596369 1 8.56
CHEMBL3596370 1 8.25
CHEMBL3596368 1 8.05
CHEMBL3596366 1 7.81
CHEMBL3596371 1 7.74
CHEMBL3596372 1 7.42
CHEMBL3596367 1 6.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL610012 Ki = 0.407 nM 9.39
CHEMBL567175 NALTRINDOLE Ki = 0.457 nM 9.34
CHEMBL3596364 Ki = 1.11 nM 8.96
CHEMBL3596365 Ki = 1.94 nM 8.71
CHEMBL3596363 Ki = 2.71 nM 8.57
CHEMBL3596369 Ki = 2.77 nM 8.56
CHEMBL3596370 Ki = 5.58 nM 8.25
CHEMBL3596368 Ki = 8.89 nM 8.05
CHEMBL3596366 Ki = 15.5 nM 7.81
CHEMBL3596371 Ki = 18.2 nM 7.74
CHEMBL3596372 Ki = 37.8 nM 7.42
CHEMBL3596367 Ki = 134.0 nM 6.87