Assay Detail
Binding
CHEMBL3598352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69,593 from human KOR expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.82 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610012 | — | — | 1 | 7.96 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.83 |
| CHEMBL3596364 | — | — | 1 | 7.13 |
| CHEMBL3596369 | — | — | 1 | 6.50 |
| CHEMBL3596365 | — | — | 1 | 6.40 |
| CHEMBL3596363 | — | — | 1 | 6.33 |
| CHEMBL3596368 | — | — | 1 | 6.32 |
| CHEMBL3596370 | — | — | 1 | 6.07 |
| CHEMBL3596366 | — | — | 1 | - |
| CHEMBL3596367 | — | — | 1 | - |
| CHEMBL3596371 | — | — | 1 | - |
| CHEMBL3596372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610012 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL3596364 | — | Ki | = | 74.3 | nM | 7.13 |
| CHEMBL3596369 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL3596365 | — | Ki | = | 397.0 | nM | 6.40 |
| CHEMBL3596363 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL3596368 | — | Ki | = | 477.0 | nM | 6.32 |
| CHEMBL3596370 | — | Ki | = | 854.0 | nM | 6.07 |
| CHEMBL3596366 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3596367 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3596371 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3596372 | — | Ki | > | 1000.0 | nM | - |