Assay Detail
Binding
CHEMBL3598469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-citalopram from gerbil SERT expressed in HEK293 cell membranes incubated for 60 mins by liquid scintillation counting method
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gerbillinae |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.81 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3596476 | — | — | 1 | 8.82 |
| CHEMBL3596474 | — | — | 1 | 8.74 |
| CHEMBL3596489 | — | — | 1 | 8.57 |
| CHEMBL3596488 | — | — | 1 | 8.51 |
| CHEMBL3596464 | — | — | 1 | 8.46 |
| CHEMBL3596478 | — | — | 1 | 8.46 |
| CHEMBL3596486 | — | — | 1 | 8.43 |
| CHEMBL3596455 | — | — | 1 | 8.43 |
| CHEMBL3596490 | — | — | 1 | 8.40 |
| CHEMBL3596483 | — | — | 1 | 8.40 |
| CHEMBL3596458 | — | — | 1 | 8.39 |
| CHEMBL3596470 | — | — | 1 | 8.38 |
| CHEMBL3596465 | — | — | 1 | 8.38 |
| CHEMBL3596468 | — | — | 1 | 8.20 |
| CHEMBL3596461 | — | — | 1 | 8.19 |
| CHEMBL3596477 | — | — | 1 | 8.19 |
| CHEMBL3596485 | — | — | 1 | 8.15 |
| CHEMBL3596479 | — | — | 1 | 8.14 |
| CHEMBL3596200 | — | — | 1 | 8.13 |
| CHEMBL3596462 | — | — | 1 | 8.12 |
| CHEMBL3596452 | — | — | 1 | 8.07 |
| CHEMBL3596484 | — | — | 1 | 8.05 |
| CHEMBL3596492 | — | — | 1 | 8.02 |
| CHEMBL3596454 | — | — | 1 | 8.02 |
| CHEMBL3596491 | — | — | 1 | 8.00 |
| CHEMBL3596467 | — | — | 1 | 8.00 |
| CHEMBL3596463 | — | — | 1 | 7.89 |
| CHEMBL3596480 | — | — | 1 | 7.85 |
| CHEMBL3596466 | — | — | 1 | 7.85 |
| CHEMBL3596482 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3596476 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3596474 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3596489 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3596488 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3596464 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3596478 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3596486 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3596455 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3596490 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3596483 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3596458 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3596470 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3596465 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3596468 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3596477 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3596461 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3596485 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3596479 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3596200 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3596462 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3596452 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3596484 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3596492 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3596454 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3596491 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3596467 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3596463 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3596480 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3596466 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3596482 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3596456 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3596457 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3596475 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3596481 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3596471 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3596469 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3596473 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3596449 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3596472 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3596487 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3596453 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3596451 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3596450 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3596459 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3596460 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3596493 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3596494 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3596496 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3596495 | — | IC50 | = | 2100.0 | nM | 5.68 |