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Assay Detail

CHEMBL3598548

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Binding
Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysis
ChEMBL ↗
44
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosylhomocysteinase (CHEMBL2664) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
Nakao A, Suzuki H, Ueno H, Iwasaki H, Setsuta T, Kashima A, Sunada S.
Bioorg Med Chem (2015) 23 : 4952 -4969
PubMed 26037610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 6.51 8.30
Inhibition 8 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3322562 — — 1 8.30
CHEMBL3597832 — — 1 8.07
CHEMBL3322547 — — 1 7.89
CHEMBL3322550 — — 1 7.36
CHEMBL3322549 — — 1 7.31
CHEMBL3597818 — — 1 7.31
CHEMBL3322540 — — 1 7.28
CHEMBL3597817 — — 1 7.22
CHEMBL3597816 — — 1 7.16
CHEMBL3322541 — — 1 7.09
CHEMBL3597821 — — 1 6.96
CHEMBL3322553 — — 1 6.89
CHEMBL3597823 — — 1 6.82
CHEMBL3322548 — — 1 6.70
CHEMBL3322545 — — 1 6.64
CHEMBL3322552 — — 1 6.50
CHEMBL3322551 — — 1 6.48
CHEMBL3322534 — — 1 6.47
CHEMBL3322533 — — 1 6.42
CHEMBL3322542 — — 1 6.28
CHEMBL3322532 — — 1 6.28
CHEMBL3597822 — — 1 6.22
CHEMBL3597813 — — 1 6.19
CHEMBL3322546 — — 1 6.05
CHEMBL3322535 — — 1 6.01
CHEMBL3597819 — — 1 5.92
CHEMBL3597820 — — 1 5.82
CHEMBL3597812 — — 1 5.64
CHEMBL3322539 — — 1 5.57
CHEMBL3322544 — — 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3322562 — IC50 = 5.0 nM 8.30
CHEMBL3597832 — IC50 = 8.5 nM 8.07
CHEMBL3322547 — IC50 = 13.0 nM 7.89
CHEMBL3322550 — IC50 = 44.0 nM 7.36
CHEMBL3322549 — IC50 = 49.0 nM 7.31
CHEMBL3597818 — IC50 = 49.0 nM 7.31
CHEMBL3322540 — IC50 = 52.0 nM 7.28
CHEMBL3597817 — IC50 = 60.0 nM 7.22
CHEMBL3597816 — IC50 = 70.0 nM 7.16
CHEMBL3322541 — IC50 = 81.0 nM 7.09
CHEMBL3597821 — IC50 = 110.0 nM 6.96
CHEMBL3322553 — IC50 = 130.0 nM 6.89
CHEMBL3597823 — IC50 = 150.0 nM 6.82
CHEMBL3322548 — IC50 = 200.0 nM 6.70
CHEMBL3322545 — IC50 = 230.0 nM 6.64
CHEMBL3322552 — IC50 = 320.0 nM 6.50
CHEMBL3322551 — IC50 = 330.0 nM 6.48
CHEMBL3322534 — IC50 = 340.0 nM 6.47
CHEMBL3322533 — IC50 = 380.0 nM 6.42
CHEMBL3322542 — IC50 = 530.0 nM 6.28
CHEMBL3322532 — IC50 = 530.0 nM 6.28
CHEMBL3597822 — IC50 = 600.0 nM 6.22
CHEMBL3597813 — IC50 = 640.0 nM 6.19
CHEMBL3322546 — IC50 = 890.0 nM 6.05
CHEMBL3322535 — IC50 = 970.0 nM 6.01
CHEMBL3597819 — IC50 = 1200.0 nM 5.92
CHEMBL3597820 — IC50 = 1500.0 nM 5.82
CHEMBL3597812 — IC50 = 2300.0 nM 5.64
CHEMBL3322539 — IC50 = 2700.0 nM 5.57
CHEMBL3322544 — IC50 = 4600.0 nM 5.34
CHEMBL3321765 — IC50 = 8780.0 nM 5.06
CHEMBL3322536 — IC50 = 11360.0 nM 4.95
CHEMBL3322538 — IC50 = 17000.0 nM 4.77
CHEMBL3322537 — IC50 > 100000.0 nM -
CHEMBL3597815 — IC50 > 100000.0 nM -
CHEMBL3597831 — Inhibition - % -
CHEMBL3597830 — Inhibition - % -
CHEMBL3597814 — IC50 > 100000.0 nM -
CHEMBL3597829 — Inhibition - % -
CHEMBL3597824 — Inhibition - % -
CHEMBL3597825 — Inhibition - % -
CHEMBL3597826 — Inhibition - % -
CHEMBL3597827 — Inhibition - % -
CHEMBL3597828 — Inhibition - % -