Assay Detail
Functional
CHEMBL3598574
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Antimalarial activity against synchronised early trophozoite stage of Plasmodium falciparum 3D7 assessed as parasite growth inhibition measured after two invasion cycles by flow cytometric analysis
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 10 | - | - |
| IC50 | 4 | 4.20 | 4.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170724 | — | — | 1 | 4.20 |
| CHEMBL3596396 | — | — | 1 | - |
| CHEMBL47940 | — | — | 1 | - |
| CHEMBL3596397 | — | — | 1 | - |
| CHEMBL3596398 | — | — | 1 | - |
| CHEMBL3596399 | — | — | 1 | - |
| CHEMBL3596400 | — | — | 1 | - |
| CHEMBL3596401 | — | — | 1 | - |
| CHEMBL3596402 | — | — | 1 | - |
| CHEMBL3596403 | — | — | 1 | - |
| CHEMBL3596404 | — | — | 1 | - |
| CHEMBL3596405 | — | — | 1 | - |
| CHEMBL3596406 | — | — | 1 | - |
| CHEMBL3596407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170724 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3596396 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL47940 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3596397 | — | GI | - | — | - | |
| CHEMBL3596398 | — | GI | - | — | - | |
| CHEMBL3596399 | — | IC50 | < | 31000.0 | nM | - |
| CHEMBL3596400 | — | GI | - | — | - | |
| CHEMBL3596401 | — | GI | - | — | - | |
| CHEMBL3596402 | — | GI | - | — | - | |
| CHEMBL3596403 | — | GI | - | — | - | |
| CHEMBL3596404 | — | GI | - | — | - | |
| CHEMBL3596405 | — | GI | - | — | - | |
| CHEMBL3596406 | — | GI | - | — | - | |
| CHEMBL3596407 | — | GI | - | — | - |