Assay Detail
Binding
CHEMBL3598576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Escherichia coli FimH
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type 1 fimbrin D-mannose specific adhesin (CHEMBL4837) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Branched -d-mannopyranosides: a new class of potent FimH antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.30 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092402 | — | — | 1 | 9.19 |
| CHEMBL1170455 | — | — | 1 | 8.30 |
| CHEMBL1172750 | — | — | 1 | 7.70 |
| CHEMBL195368 | — | — | 1 | 5.66 |
| CHEMBL469448 | D-MANNOSE | 2.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092402 | — | Kd | = | 0.65 | nM | 9.19 |
| CHEMBL1170455 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL1172750 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL195368 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL469448 | D-MANNOSE | Kd | = | 2300.0 | nM | 5.64 |