Assay Detail
Binding
CHEMBL3598895
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Antagonist activity at orexin-2 receptor (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent trends in orexin research--2010 to 2015.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.57 | 9.52 |
| IC50 | 3 | 7.32 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107822 | FILOREXANT | 2.0 | 1 | 9.52 |
| CHEMBL3597953 | — | — | 1 | 9.00 |
| CHEMBL3597955 | — | — | 1 | 8.40 |
| CHEMBL3597957 | — | — | 1 | 7.87 |
| CHEMBL3597956 | — | — | 1 | 7.72 |
| CHEMBL3597954 | — | — | 1 | 7.36 |
| CHEMBL2413367 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107822 | FILOREXANT | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3597953 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3597955 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3597957 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL3597956 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3597954 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2413367 | — | IC50 | = | 417.0 | nM | 6.38 |