Assay Detail
Binding
CHEMBL3598919
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Inhibition of human HDAC9
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.50 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 8.42 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 1 | 7.62 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.60 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 6.41 |
| CHEMBL356769 | TUBACIN | — | 1 | 6.29 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.10 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 5.50 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1851943 | PRACINOSTAT | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL356769 | TUBACIN | Ki | = | 509.3 | nM | 6.29 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 9000.0 | nM | 5.05 |