Assay Detail
Binding
CHEMBL3598920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC6
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.14 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | — | 1 | 9.05 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.82 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 8.80 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.48 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 8.38 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.02 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 7.77 |
| CHEMBL2103863 | ABEXINOSTAT | 3.0 | 1 | 7.77 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 6.87 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2018302 | TUBASTATIN A | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL2105763 | QUISINOSTAT | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL2103863 | ABEXINOSTAT | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL314389 | OXAMFLATIN | Ki | = | 135.9 | nM | 6.87 |
| CHEMBL1851943 | PRACINOSTAT | Ki | = | 247.0 | nM | 6.61 |