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Assay Detail

CHEMBL3599632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
ChEMBL ↗
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R.
J Med Chem (2015) 58 : 5789 -5807
PubMed 26132075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 7.14 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3597212 — — 1 8.89
CHEMBL3597215 — — 1 8.40
CHEMBL107 COLCHICINE 4.0 1 8.30
CHEMBL3597223 — — 1 8.15
CHEMBL3597205 — — 1 8.05
CHEMBL3597217 — — 1 8.05
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.89
CHEMBL3597224 — — 1 7.82
CHEMBL3597221 — — 1 7.72
CHEMBL3597219 — — 1 7.70
CHEMBL3597207 — — 1 7.70
CHEMBL3597214 — — 1 7.60
CHEMBL3597220 — — 1 7.52
CHEMBL3597206 — — 1 7.52
CHEMBL3597213 — — 1 7.52
CHEMBL3597208 — — 1 7.46
CHEMBL3597216 — — 1 7.30
CHEMBL3597209 — — 1 7.26
CHEMBL3597191 — — 1 7.19
CHEMBL3597210 — — 1 7.10
CHEMBL3597190 — — 1 7.10
CHEMBL3597204 — — 1 7.00
CHEMBL3597203 — — 1 6.77
CHEMBL3597222 — — 1 6.70
CHEMBL3597218 — — 1 6.70
CHEMBL3597202 — — 1 6.70
CHEMBL3597201 — — 1 6.62
CHEMBL3597188 — — 1 6.58
CHEMBL3597197 — — 1 6.55
CHEMBL3597187 — — 1 6.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3597212 — IC50 = 1.3 nM 8.89
CHEMBL3597215 — IC50 = 4.0 nM 8.40
CHEMBL107 COLCHICINE IC50 = 5.0 nM 8.30
CHEMBL3597223 — IC50 = 7.0 nM 8.15
CHEMBL3597205 — IC50 = 9.0 nM 8.05
CHEMBL3597217 — IC50 = 9.0 nM 8.05
CHEMBL67 COMBRETASTATIN A4 IC50 = 13.0 nM 7.89
CHEMBL3597224 — IC50 = 15.0 nM 7.82
CHEMBL3597221 — IC50 = 19.0 nM 7.72
CHEMBL3597219 — IC50 = 20.0 nM 7.70
CHEMBL3597207 — IC50 = 20.0 nM 7.70
CHEMBL3597214 — IC50 = 25.0 nM 7.60
CHEMBL3597220 — IC50 = 30.0 nM 7.52
CHEMBL3597213 — IC50 = 30.0 nM 7.52
CHEMBL3597206 — IC50 = 30.0 nM 7.52
CHEMBL3597208 — IC50 = 35.0 nM 7.46
CHEMBL3597216 — IC50 = 50.0 nM 7.30
CHEMBL3597209 — IC50 = 55.0 nM 7.26
CHEMBL3597191 — IC50 = 65.0 nM 7.19
CHEMBL3597210 — IC50 = 80.0 nM 7.10
CHEMBL3597190 — IC50 = 80.0 nM 7.10
CHEMBL3597204 — IC50 = 100.0 nM 7.00
CHEMBL3597203 — IC50 = 170.0 nM 6.77
CHEMBL3597222 — IC50 = 200.0 nM 6.70
CHEMBL3597218 — IC50 = 200.0 nM 6.70
CHEMBL3597202 — IC50 = 200.0 nM 6.70
CHEMBL3597201 — IC50 = 240.0 nM 6.62
CHEMBL3597188 — IC50 = 260.0 nM 6.58
CHEMBL3597197 — IC50 = 280.0 nM 6.55
CHEMBL3597187 — IC50 = 290.0 nM 6.54
CHEMBL3597200 — IC50 = 300.0 nM 6.52
CHEMBL3597199 — IC50 = 310.0 nM 6.51
CHEMBL3597194 — IC50 = 320.0 nM 6.50
CHEMBL3597198 — IC50 = 330.0 nM 6.48
CHEMBL3597185 — IC50 = 400.0 nM 6.40
CHEMBL3597186 — IC50 = 430.0 nM 6.37
CHEMBL3597195 — IC50 = 530.0 nM 6.28
CHEMBL3597211 — IC50 = 600.0 nM 6.22
CHEMBL3597196 — IC50 = 700.0 nM 6.16
CHEMBL3597192 — IC50 = 1400.0 nM 5.85
CHEMBL3597189 — IC50 > 5000.0 nM -
CHEMBL3597193 — IC50 > 5000.0 nM -