Assay Detail
Binding
CHEMBL3599874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation counting
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.51 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3597643 | — | — | 1 | 9.93 |
| CHEMBL3597645 | — | — | 1 | 9.89 |
| CHEMBL3597644 | — | — | 1 | 9.76 |
| CHEMBL3596212 | — | — | 1 | 9.61 |
| CHEMBL68740 | — | — | 1 | 9.55 |
| CHEMBL3597635 | — | — | 1 | 9.46 |
| CHEMBL3597641 | — | — | 1 | 9.41 |
| CHEMBL3597639 | — | — | 1 | 9.24 |
| CHEMBL3597642 | — | — | 1 | 9.04 |
| CHEMBL1627310 | — | — | 1 | 8.74 |
| CHEMBL1627305 | — | — | 1 | 8.73 |
| CHEMBL3597637 | — | — | 1 | 8.70 |
| CHEMBL3597650 | — | — | 1 | 8.67 |
| CHEMBL3597647 | — | — | 1 | 8.60 |
| CHEMBL127317 | — | — | 1 | 8.46 |
| CHEMBL3597636 | — | — | 1 | 8.44 |
| CHEMBL3597640 | — | — | 1 | 8.09 |
| CHEMBL3597638 | — | — | 1 | 7.50 |
| CHEMBL3597649 | — | — | 1 | 7.47 |
| CHEMBL3597654 | — | — | 1 | 7.42 |
| CHEMBL3597651 | — | — | 1 | 7.35 |
| CHEMBL3597652 | — | — | 1 | 7.28 |
| CHEMBL3597648 | — | — | 1 | 7.28 |
| CHEMBL3597653 | — | — | 1 | 7.16 |
| CHEMBL3597646 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3597643 | — | Ki | = | 0.118 | nM | 9.93 |
| CHEMBL3597645 | — | Ki | = | 0.128 | nM | 9.89 |
| CHEMBL3597644 | — | Ki | = | 0.173 | nM | 9.76 |
| CHEMBL3596212 | — | Ki | = | 0.244 | nM | 9.61 |
| CHEMBL68740 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL3597635 | — | Ki | = | 0.351 | nM | 9.46 |
| CHEMBL3597641 | — | Ki | = | 0.392 | nM | 9.41 |
| CHEMBL3597639 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL3597642 | — | Ki | = | 0.907 | nM | 9.04 |
| CHEMBL1627310 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1627305 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL3597637 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL3597650 | — | Ki | = | 2.14 | nM | 8.67 |
| CHEMBL3597647 | — | Ki | = | 2.51 | nM | 8.60 |
| CHEMBL127317 | — | Ki | = | 3.46 | nM | 8.46 |
| CHEMBL3597636 | — | Ki | = | 3.63 | nM | 8.44 |
| CHEMBL3597640 | — | Ki | = | 8.05 | nM | 8.09 |
| CHEMBL3597638 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL3597649 | — | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL3597654 | — | Ki | = | 37.7 | nM | 7.42 |
| CHEMBL3597651 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL3597652 | — | Ki | = | 52.9 | nM | 7.28 |
| CHEMBL3597648 | — | Ki | = | 53.1 | nM | 7.28 |
| CHEMBL3597653 | — | Ki | = | 69.9 | nM | 7.16 |
| CHEMBL3597646 | — | Ki | = | 97.9 | nM | 7.01 |