Assay Detail
Binding
CHEMBL3600079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig microtubule polymerization after 30 mins by turbidimetric assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.34 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426932 | — | — | 1 | 5.63 |
| CHEMBL3597142 | — | — | 1 | 5.45 |
| CHEMBL3597126 | — | — | 1 | 5.41 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.30 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.23 |
| CHEMBL3597129 | — | — | 1 | 5.04 |
| CHEMBL3597130 | — | — | 1 | - |
| CHEMBL3597138 | — | — | 1 | - |
| CHEMBL3597141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426932 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3597142 | — | IC50 | = | 3554.0 | nM | 5.45 |
| CHEMBL3597126 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL107 | COLCHICINE | IC50 | = | 5023.0 | nM | 5.30 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5907.0 | nM | 5.23 |
| CHEMBL3597129 | — | IC50 | = | 9042.0 | nM | 5.04 |
| CHEMBL3597130 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3597141 | — | IC50 | > | 10000.0 | nM | - |