Assay Detail
Functional
CHEMBL3600084
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Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.75 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL3426932 | — | — | 1 | 7.00 |
| CHEMBL3597126 | — | — | 1 | 6.38 |
| CHEMBL3597142 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3426932 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3597126 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL3597142 | — | IC50 | = | 1160.0 | nM | 5.94 |