Assay Detail
Binding
CHEMBL3602054
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.25 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.06 |
| CHEMBL3601087 | — | — | 1 | 5.89 |
| CHEMBL3601089 | — | — | 1 | 5.79 |
| CHEMBL3601092 | — | — | 1 | - |
| CHEMBL3601090 | — | — | 1 | - |
| CHEMBL3601088 | — | — | 1 | - |
| CHEMBL3600934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3601087 | — | EC50 | = | 1298.0 | nM | 5.89 |
| CHEMBL3601089 | — | EC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL3601092 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3601090 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3601088 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3600934 | — | EC50 | > | 100000.0 | nM | - |