Assay Detail
Functional
CHEMBL3602178
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Antiviral activity against Human cytomegalovirus AD169 expressing GFP infected in HFF assessed as inhibition of viral replication after 7 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.10 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601866 | — | — | 1 | 7.40 |
| CHEMBL3601865 | — | — | 1 | 6.51 |
| CHEMBL3601864 | — | — | 1 | 5.98 |
| CHEMBL2088546 | — | — | 1 | 5.68 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.58 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 5.42 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | - |
| CHEMBL3601867 | — | — | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL2088548 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601866 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3601865 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3601864 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL2088546 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL307261 | ARTENIMOL | IC50 | > | 10000.0 | nM | - |
| CHEMBL3601867 | — | IC50 | - | — | - | |
| CHEMBL269671 | ARTEMISININ | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088548 | — | IC50 | > | 10000.0 | nM | - |