Assay Detail
Binding
CHEMBL3602209
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Displacement of [3H]CGP54626 from GABA-B receptor (unknown origin) by radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Activation of the γ-Aminobutyric Acid Type B (GABA(B)) Receptor by Agonists and Positive Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.63 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL701 | BACLOFEN | 4.0 | 1 | 5.22 |
| CHEMBL53073 | — | — | 1 | 4.04 |
| CHEMBL315818 | PHENIBUT | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL701 | BACLOFEN | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL53073 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL315818 | PHENIBUT | Ki | = | 177000.0 | nM | - |