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Assay Detail

CHEMBL3602225

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Functional
Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of parasite growth
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

From hybrid compounds to targeted drug delivery in antimalarial therapy.
Oliveira R, Miranda D, Magalhães J, Capela R, Perry MJ, O'Neill PM, Moreira R, Lopes F.
Bioorg Med Chem (2015) 23 : 5120 -5130
PubMed 25913864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.37 8.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1783732 1 8.38
CHEMBL3600961 1 8.29
CHEMBL3601443 1 8.29
CHEMBL3286857 1 8.01
CHEMBL3601452 1 8.00
CHEMBL3221874 1 7.82
CHEMBL3601446 1 7.73
CHEMBL3108887 1 7.66
CHEMBL3601447 1 7.58
CHEMBL469912 PUROMYCIN 2.0 1 7.38
CHEMBL3286864 1 7.32
CHEMBL3600960 1 7.29
CHEMBL224025 1 7.11
CHEMBL2435702 1 7.02
CHEMBL3601451 1 6.75
CHEMBL1774611 1 6.52
CHEMBL3601450 1 6.22
CHEMBL2042177 1 5.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1783732 IC50 = 4.21 nM 8.38
CHEMBL3600961 IC50 = 5.1 nM 8.29
CHEMBL3601443 IC50 = 5.1 nM 8.29
CHEMBL3286857 IC50 = 9.8 nM 8.01
CHEMBL3601452 IC50 = 10.0 nM 8.00
CHEMBL3221874 IC50 = 15.0 nM 7.82
CHEMBL3601446 IC50 = 18.5 nM 7.73
CHEMBL3108887 IC50 = 22.0 nM 7.66
CHEMBL3601447 IC50 = 26.2 nM 7.58
CHEMBL469912 PUROMYCIN IC50 = 42.0 nM 7.38
CHEMBL3286864 IC50 = 48.1 nM 7.32
CHEMBL3600960 IC50 = 51.0 nM 7.29
CHEMBL224025 IC50 = 77.0 nM 7.11
CHEMBL2435702 IC50 = 95.0 nM 7.02
CHEMBL3601451 IC50 = 180.0 nM 6.75
CHEMBL1774611 IC50 = 300.0 nM 6.52
CHEMBL3601450 IC50 = 600.0 nM 6.22
CHEMBL2042177 IC50 = 4890.0 nM 5.31