Assay Detail
Binding
CHEMBL3602290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.35 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601322 | — | — | 1 | 5.89 |
| CHEMBL3601397 | — | — | 1 | 4.80 |
| CHEMBL3601324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601322 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3601397 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3601324 | — | IC50 | > | 30000.0 | nM | - |