Assay Detail
Binding
CHEMBL3602308
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Inhibition of dog MDM2 by TR-FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
E3 ubiquitin-protein ligase Mdm2 (CHEMBL3600278) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.84 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.98 |
| CHEMBL3601398 | CGM-097 | 1.0 | 1 | 7.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191334 | NUTLIN-3 | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL3601398 | CGM-097 | Ki | = | 20.5 | nM | 7.69 |