Assay Detail
Binding
CHEMBL3602550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human P2X7 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.60 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338117 | — | — | 1 | 7.51 |
| CHEMBL28324 | — | — | 1 | 7.00 |
| CHEMBL10 | SB-203580 | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338117 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL28324 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL10 | SB-203580 | IC50 | = | 5000.0 | nM | 5.30 |