Assay Detail
Binding
CHEMBL3602663
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Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thyrotropin-releasing hormone receptor 2 (CHEMBL3600274) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | 8.15 |
| CHEMBL3601783 | — | — | 1 | - |
| CHEMBL3601784 | — | — | 1 | - |
| CHEMBL3601785 | — | — | 1 | - |
| CHEMBL3601786 | — | — | 1 | - |
| CHEMBL3600444 | — | — | 1 | - |
| CHEMBL3600445 | — | — | 1 | - |
| CHEMBL3600446 | — | — | 1 | - |
| CHEMBL3600447 | — | — | 1 | - |
| CHEMBL3600448 | — | — | 1 | - |
| CHEMBL3600450 | — | — | 1 | - |
| CHEMBL3601782 | — | — | 1 | - |
| CHEMBL3601781 | — | — | 1 | - |
| CHEMBL3600454 | — | — | 1 | - |
| CHEMBL3600453 | — | — | 1 | - |
| CHEMBL3600452 | — | — | 1 | - |
| CHEMBL3600451 | — | — | 1 | - |
| CHEMBL3600449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3601783 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601784 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601785 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601786 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600444 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600445 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600446 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600447 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600448 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600450 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601782 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601781 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600454 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600453 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600452 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600451 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600449 | — | IC50 | > | 50000.0 | nM | - |