Assay Detail
Binding
CHEMBL3602695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 HXB2 gp41 N-terminal heptad repeat-mediated fusion between infected HL2/3 cells to target TZM-bl cells after 6 hrs by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HL2/3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Envelope glycoprotein gp160 (CHEMBL3520) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) |
Publication
The N-Terminal T-T Motif of a Third-Generation HIV-1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.65 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600949 | — | — | 1 | 9.47 |
| CHEMBL529902 | — | — | 1 | 9.46 |
| CHEMBL3600950 | — | — | 1 | 9.36 |
| CHEMBL428607 | — | — | 1 | 9.08 |
| CHEMBL411406 | — | — | 1 | 9.07 |
| CHEMBL3600952 | — | — | 1 | 8.66 |
| CHEMBL3600951 | — | — | 1 | 8.64 |
| CHEMBL3600954 | — | — | 1 | 7.75 |
| CHEMBL3600953 | — | — | 1 | 7.75 |
| CHEMBL3600956 | — | — | 1 | 7.23 |
| CHEMBL3600955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600949 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL529902 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3600950 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL428607 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL411406 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL3600952 | — | IC50 | = | 2.18 | nM | 8.66 |
| CHEMBL3600951 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL3600954 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL3600953 | — | IC50 | = | 17.74 | nM | 7.75 |
| CHEMBL3600956 | — | IC50 | = | 58.79 | nM | 7.23 |
| CHEMBL3600955 | — | IC50 | > | 2250.0 | nM | - |