Assay Detail
Functional
CHEMBL3603055
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of parasite growth after 48 hrs by LDH assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.91 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021640 | — | — | 1 | 6.46 |
| CHEMBL3600468 | — | — | 1 | 6.44 |
| CHEMBL255056 | — | — | 1 | 6.41 |
| CHEMBL252753 | — | — | 1 | 6.37 |
| CHEMBL2021632 | — | — | 1 | 6.34 |
| CHEMBL401339 | — | — | 1 | 6.33 |
| CHEMBL400544 | — | — | 1 | 6.28 |
| CHEMBL3600467 | — | — | 1 | 6.09 |
| CHEMBL3600549 | — | — | 1 | 6.08 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.03 |
| CHEMBL2021659 | — | — | 1 | 5.68 |
| CHEMBL1187001 | — | — | 1 | 5.58 |
| CHEMBL410770 | — | — | 1 | 5.52 |
| CHEMBL3600553 | — | — | 1 | 5.46 |
| CHEMBL401340 | — | — | 1 | 5.36 |
| CHEMBL3600555 | — | — | 1 | 5.36 |
| CHEMBL1186058 | — | — | 1 | 5.31 |
| CHEMBL3600550 | — | — | 1 | 5.22 |
| CHEMBL401273 | — | — | 1 | - |
| CHEMBL3600556 | — | — | 1 | - |
| CHEMBL3600554 | — | — | 1 | - |
| CHEMBL3600552 | — | — | 1 | - |
| CHEMBL3600551 | — | — | 1 | - |
| CHEMBL1187774 | — | — | 1 | - |
| CHEMBL2021630 | — | — | 1 | - |
| CHEMBL3600466 | — | — | 1 | - |
| CHEMBL1186370 | — | — | 1 | - |
| CHEMBL252424 | — | — | 1 | - |
| CHEMBL2021669 | — | — | 1 | - |
| CHEMBL1187082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021640 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3600468 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL255056 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL252753 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2021632 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL401339 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL400544 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3600467 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3600549 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2021659 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1187001 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL410770 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL3600553 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3600555 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL401340 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1186058 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL3600550 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL401273 | — | IC50 | > | 6880.0 | nM | - |
| CHEMBL3600556 | — | IC50 | > | 6900.0 | nM | - |
| CHEMBL3600554 | — | IC50 | > | 7300.0 | nM | - |
| CHEMBL3600552 | — | IC50 | > | 6600.0 | nM | - |
| CHEMBL3600551 | — | IC50 | > | 6900.0 | nM | - |
| CHEMBL1187774 | — | IC50 | > | 7720.0 | nM | - |
| CHEMBL2021630 | — | IC50 | - | — | - | |
| CHEMBL3600466 | — | IC50 | > | 7050.0 | nM | - |
| CHEMBL1186370 | — | IC50 | - | — | - | |
| CHEMBL252424 | — | IC50 | > | 7140.0 | nM | - |
| CHEMBL2021669 | — | IC50 | > | 6820.0 | nM | - |
| CHEMBL1187082 | — | IC50 | > | 8150.0 | nM | - |
| CHEMBL3600463 | — | IC50 | > | 7010.0 | nM | - |
| CHEMBL3600464 | — | IC50 | - | — | - | |
| CHEMBL3600465 | — | IC50 | > | 7140.0 | nM | - |