Assay Detail
Functional
CHEMBL3603138
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Antiviral activity against HSV-2 186 infected in African green monkey Vero cells assessed as inhibition of viral yield after 48 hrs by crystal violet staining
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601025 | — | — | 1 | 6.22 |
| CHEMBL3601026 | — | — | 1 | 6.05 |
| CHEMBL3601028 | — | — | 1 | 6.05 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.80 |
| CHEMBL3601027 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601025 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3601026 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3601028 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3601027 | — | IC50 | = | 7200.0 | nM | 5.14 |