Assay Detail
Binding
CHEMBL3603304
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Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 secs followed by compound washout for 4 mins by two-electrode voltage-clamp electrophysiology assay
9
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian α7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.25 | 4.25 |
| pEC50 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600666 | — | — | 2 | 4.25 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 2 | - |
| CHEMBL3 | NICOTINE | 4.0 | 2 | - |
| CHEMBL3600667 | — | — | 1 | - |
| CHEMBL3600668 | — | — | 1 | - |
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600666 | — | EC50 | = | 56234.13 | nM | 4.25 |
| CHEMBL3600666 | — | EC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 208929.61 | nM | - |
| CHEMBL3 | NICOTINE | EC50 | = | 109647.82 | nM | - |
| CHEMBL3600667 | — | pEC50 | - | — | - | |
| CHEMBL3600668 | — | pEC50 | - | — | - | |
| CHEMBL18041 | ZACOPRIDE | pEC50 | - | — | - | |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 205300.0 | nM | - |
| CHEMBL3 | NICOTINE | EC50 | = | 108700.0 | nM | - |