Assay Detail
Binding
CHEMBL3603319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2 (unknown origin) by Z'-Lyte assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Selective Covalent Janus Kinase 3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.90 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601231 | — | — | 1 | 7.75 |
| CHEMBL3601120 | — | — | 1 | 7.50 |
| CHEMBL3601115 | — | — | 1 | 7.29 |
| CHEMBL3601242 | — | — | 1 | 6.97 |
| CHEMBL3601235 | — | — | 1 | 6.46 |
| CHEMBL3601862 | — | — | 1 | 6.38 |
| CHEMBL3601223 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601231 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL3601120 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3601115 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3601242 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3601235 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL3601862 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL3601223 | — | IC50 | = | 1050.0 | nM | 5.98 |