Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3603390

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP incubated for 45 mins by ADP-Glo kinase Assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phosphatidylinositol 4-kinase beta (CHEMBL3268) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα).
Raubo P, Andrews DM, McKelvie JC, Robb GR, Smith JM, Swarbrick ME, Waring MJ.
Bioorg Med Chem Lett (2015) 25 : 3189 -3193
PubMed 26087940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 5.88 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3600785 — — 1 6.60
CHEMBL3600782 — — 1 6.50
CHEMBL3600778 — — 1 6.50
CHEMBL3600777 — — 1 6.50
CHEMBL3600685 — — 1 6.50
CHEMBL3600781 — — 1 6.40
CHEMBL97245 — — 1 6.30
CHEMBL3600691 — — 1 6.30
CHEMBL3600694 — — 1 6.30
CHEMBL3600784 — — 1 6.20
CHEMBL3600767 — — 1 6.20
CHEMBL3600701 — — 1 6.20
CHEMBL3600683 — — 1 6.20
CHEMBL3600684 — — 1 6.20
CHEMBL3600776 — — 1 6.10
CHEMBL3600690 — — 1 6.10
CHEMBL3600769 — — 1 6.00
CHEMBL1645107 — — 1 6.00
CHEMBL1645105 — — 1 6.00
CHEMBL3600695 — — 1 6.00
CHEMBL3600688 — — 1 6.00
CHEMBL3600698 — — 1 6.00
CHEMBL3600687 — — 1 5.90
CHEMBL3600770 — — 1 5.90
CHEMBL3600768 — — 1 5.90
CHEMBL3600779 — — 1 5.80
CHEMBL3600771 — — 1 5.80
CHEMBL3600692 — — 1 5.80
CHEMBL3600689 — — 1 5.80
CHEMBL3600772 — — 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3600785 — IC50 = 251.19 nM 6.60
CHEMBL3600782 — IC50 = 316.23 nM 6.50
CHEMBL3600778 — IC50 = 316.23 nM 6.50
CHEMBL3600777 — IC50 = 316.23 nM 6.50
CHEMBL3600685 — IC50 = 316.23 nM 6.50
CHEMBL3600781 — IC50 = 398.11 nM 6.40
CHEMBL97245 — IC50 = 501.19 nM 6.30
CHEMBL3600691 — IC50 = 501.19 nM 6.30
CHEMBL3600694 — IC50 = 501.19 nM 6.30
CHEMBL3600683 — IC50 = 630.96 nM 6.20
CHEMBL3600684 — IC50 = 630.96 nM 6.20
CHEMBL3600701 — IC50 = 630.96 nM 6.20
CHEMBL3600767 — IC50 = 630.96 nM 6.20
CHEMBL3600784 — IC50 = 630.96 nM 6.20
CHEMBL3600690 — IC50 = 794.33 nM 6.10
CHEMBL3600776 — IC50 = 794.33 nM 6.10
CHEMBL3600769 — IC50 = 1000.0 nM 6.00
CHEMBL1645107 — IC50 = 1000.0 nM 6.00
CHEMBL1645105 — IC50 = 1000.0 nM 6.00
CHEMBL3600695 — IC50 = 1000.0 nM 6.00
CHEMBL3600688 — IC50 = 1000.0 nM 6.00
CHEMBL3600698 — IC50 = 1000.0 nM 6.00
CHEMBL3600687 — IC50 = 1258.93 nM 5.90
CHEMBL3600768 — IC50 = 1258.93 nM 5.90
CHEMBL3600770 — IC50 = 1258.93 nM 5.90
CHEMBL3600779 — IC50 = 1584.89 nM 5.80
CHEMBL3600771 — IC50 = 1584.89 nM 5.80
CHEMBL3600692 — IC50 = 1584.89 nM 5.80
CHEMBL3600689 — IC50 = 1584.89 nM 5.80
CHEMBL3600772 — IC50 = 1995.26 nM 5.70
CHEMBL3600774 — IC50 = 1995.26 nM 5.70
CHEMBL3600775 — IC50 = 1995.26 nM 5.70
CHEMBL3600783 — IC50 = 2511.89 nM 5.60
CHEMBL3600700 — IC50 = 2511.89 nM 5.60
CHEMBL3600696 — IC50 = 2511.89 nM 5.60
CHEMBL3600773 — IC50 = 2511.89 nM 5.60
CHEMBL3600686 — IC50 = 3162.28 nM 5.50
CHEMBL3600766 — IC50 = 3981.07 nM 5.40
CHEMBL3600699 — IC50 = 3981.07 nM 5.40
CHEMBL3600765 — IC50 = 6309.57 nM 5.20
CHEMBL3600702 — IC50 = 6309.57 nM 5.20
CHEMBL3600693 — IC50 = 7943.28 nM 5.10
CHEMBL3600780 — IC50 = 10000.0 nM 5.00
CHEMBL3600697 — IC50 = 39810.72 nM 4.40