Assay Detail
Binding
CHEMBL3603394
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Inhibition of PI3Kdelta (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plus luminescence assay
44
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.08 | 6.50 |
| pIC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600699 | — | — | 1 | 6.50 |
| CHEMBL1645105 | — | — | 1 | 6.10 |
| CHEMBL3600692 | — | — | 1 | 6.00 |
| CHEMBL3600701 | — | — | 1 | 5.90 |
| CHEMBL3600698 | — | — | 1 | 5.90 |
| CHEMBL3600691 | — | — | 1 | 5.90 |
| CHEMBL3600684 | — | — | 1 | 5.70 |
| CHEMBL3600694 | — | — | 1 | 5.70 |
| CHEMBL3600774 | — | — | 1 | 5.40 |
| CHEMBL3600683 | — | — | 1 | 5.40 |
| CHEMBL3600777 | — | — | 1 | 5.30 |
| CHEMBL3600688 | — | — | 1 | 5.20 |
| CHEMBL3600685 | — | — | 1 | 5.20 |
| CHEMBL3600695 | — | — | 1 | 5.20 |
| CHEMBL3600770 | — | — | 1 | 5.10 |
| CHEMBL3600765 | — | — | 1 | 5.10 |
| CHEMBL3600778 | — | — | 1 | 5.00 |
| CHEMBL3600767 | — | — | 1 | 5.00 |
| CHEMBL3600772 | — | — | 1 | 4.90 |
| CHEMBL3600768 | — | — | 1 | 4.90 |
| CHEMBL3600693 | — | — | 1 | 4.90 |
| CHEMBL3600689 | — | — | 1 | 4.90 |
| CHEMBL3600687 | — | — | 1 | 4.90 |
| CHEMBL3600779 | — | — | 1 | 4.90 |
| CHEMBL3600775 | — | — | 1 | 4.70 |
| CHEMBL3600773 | — | — | 1 | 4.70 |
| CHEMBL3600776 | — | — | 1 | 4.70 |
| CHEMBL3600771 | — | — | 1 | 4.70 |
| CHEMBL3600769 | — | — | 1 | 4.60 |
| CHEMBL3600766 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600699 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1645105 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3600692 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3600701 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3600698 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3600691 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3600684 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3600694 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3600774 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3600683 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3600777 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3600688 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3600685 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3600695 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3600765 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3600770 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3600778 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3600767 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3600779 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600687 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600689 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600768 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600772 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600693 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3600775 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3600773 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3600776 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3600771 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3600769 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL3600766 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3600702 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL3600686 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3600697 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3600700 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL3600781 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1645107 | — | pIC50 | - | — | - | |
| CHEMBL97245 | — | pIC50 | - | — | - | |
| CHEMBL3600696 | — | pIC50 | - | — | - | |
| CHEMBL3600690 | — | pIC50 | - | — | - | |
| CHEMBL3600780 | — | IC50 | > | 199526.23 | nM | - |
| CHEMBL3600782 | — | IC50 | > | 199526.23 | nM | - |
| CHEMBL3600783 | — | IC50 | > | 199526.23 | nM | - |
| CHEMBL3600784 | — | IC50 | > | 199526.23 | nM | - |
| CHEMBL3600785 | — | IC50 | > | 79432.82 | nM | - |