Assay Detail
Binding
CHEMBL3603396
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Inhibition of PI4K3alpha in mouse NIH3T3 cells co-expressing PDGFRbeta receptor assessed as inhibition of PDGF-induced IP1 accumulation incubated for 30 mins by HTRF based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.07 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600785 | — | — | 1 | 6.50 |
| CHEMBL3600779 | — | — | 1 | 6.30 |
| CHEMBL3600782 | — | — | 1 | 6.20 |
| CHEMBL3600784 | — | — | 1 | 6.20 |
| CHEMBL3600781 | — | — | 1 | 6.10 |
| CHEMBL3600783 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600785 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3600779 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3600782 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3600784 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3600781 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3600783 | — | IC50 | = | 7943.28 | nM | 5.10 |