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Assay Detail

CHEMBL3603632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human HT-29 cells after 72 hrs by APH assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.
Soldi R, Horrigan SK, Cholody MW, Padia J, Sorna V, Bearss J, Gilcrease G, Bhalla K, Verma A, Vankayalapati H, Sharma S.
J Med Chem (2015) 58 : 5854 -5862
PubMed 26182238 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
GI50 15 - -
IC50 1 6.70 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3601410 1 6.70
CHEMBL3601411 TEGAVIVINT 2.0 1 -
CHEMBL3601480 1 -
CHEMBL3601481 1 -
CHEMBL3601482 1 -
CHEMBL3601483 1 -
CHEMBL3601484 1 -
CHEMBL3601485 1 -
CHEMBL3601486 1 -
CHEMBL3601487 1 -
CHEMBL3601488 1 -
CHEMBL3601489 1 -
CHEMBL3601490 1 -
CHEMBL3601491 1 -
CHEMBL3601492 1 -
CHEMBL3601493 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3601410 IC50 = 200.0 nM 6.70
CHEMBL3601411 TEGAVIVINT GI50 = 90.0 nM -
CHEMBL3601480 GI50 = 600.0 nM -
CHEMBL3601481 GI50 = 190.0 nM -
CHEMBL3601482 GI50 = 140.0 nM -
CHEMBL3601483 GI50 = 30.0 nM -
CHEMBL3601484 GI50 = 20.0 nM -
CHEMBL3601485 GI50 = 80.0 nM -
CHEMBL3601486 GI50 = 470.0 nM -
CHEMBL3601487 GI50 = 60.0 nM -
CHEMBL3601488 GI50 = 90.0 nM -
CHEMBL3601489 GI50 > 100000.0 nM -
CHEMBL3601490 GI50 = 60.0 nM -
CHEMBL3601491 GI50 = 180.0 nM -
CHEMBL3601492 GI50 = 80.0 nM -
CHEMBL3601493 GI50 = 3900.0 nM -