Assay Detail
Binding
CHEMBL3603633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt/beta-catenin transcriptional activity in human HT-29 cells assessed as depletion of beta-catenin level by TCF luciferase promoter reporter assay
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.03 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601484 | — | — | 1 | 6.80 |
| CHEMBL3601488 | — | — | 1 | 6.52 |
| CHEMBL3601483 | — | — | 1 | 6.52 |
| CHEMBL3601481 | — | — | 1 | 6.52 |
| CHEMBL3601411 | TEGAVIVINT | 2.0 | 1 | 6.20 |
| CHEMBL1588525 | — | — | 1 | 6.13 |
| CHEMBL1349063 | — | — | 1 | 6.00 |
| CHEMBL3601482 | — | — | 1 | 5.75 |
| CHEMBL3601410 | — | — | 2 | 5.60 |
| CHEMBL3601486 | — | — | 1 | 5.30 |
| CHEMBL3601406 | — | — | 1 | 5.00 |
| CHEMBL3601408 | — | — | 1 | - |
| CHEMBL3601407 | — | — | 1 | - |
| CHEMBL3600396 | — | — | 1 | - |
| CHEMBL3601480 | — | — | 1 | - |
| CHEMBL3601485 | — | — | 1 | - |
| CHEMBL3601487 | — | — | 1 | - |
| CHEMBL3601409 | — | — | 1 | - |
| CHEMBL3601489 | — | — | 1 | - |
| CHEMBL3601492 | — | — | 1 | - |
| CHEMBL3601490 | — | — | 1 | - |
| CHEMBL3601493 | — | — | 1 | - |
| CHEMBL3601491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601484 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3601488 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3601481 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3601483 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3601411 | TEGAVIVINT | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1588525 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1349063 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3601482 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3601410 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3601486 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3601406 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3601408 | — | IC50 | >= | 2500.0 | nM | - |
| CHEMBL3601407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3600396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3601480 | — | IC50 | - | — | - | |
| CHEMBL3601485 | — | IC50 | - | — | - | |
| CHEMBL3601487 | — | IC50 | - | — | - | |
| CHEMBL3601409 | — | IC50 | >= | 1000.0 | nM | - |
| CHEMBL3601493 | — | IC50 | - | — | - | |
| CHEMBL3601492 | — | IC50 | - | — | - | |
| CHEMBL3601410 | — | IC50 | > | 20.0 | nM | - |
| CHEMBL3601490 | — | IC50 | - | — | - | |
| CHEMBL3601489 | — | IC50 | - | — | - | |
| CHEMBL3601491 | — | IC50 | - | — | - |